#5395 ASSOCIATION BETWEEN PARABEN EXPOSURE AND EARLY RENAL INJURY IN A MIDDLE-AGED ADULT IN TAIWAN

Abstract Background and Aims Parabens are a class of preservatives used in the cosmetics industry widely people's daily lives, including personal care products (PCPs), pharmaceuticals food. Epidemiological studies concerning relations exposure to parabens with renal function were limited. We aimed investigate potential sources paraben exposure, estimate intake (DI) four based on their urinary levels association between middle-aged adult population Taiwan. Method recruited 591 subjects aged from ≥40 <65 years old (yrs) who have participated Taiwan Environmental Survey for Toxicants (TEST) study 2013-2016. Urinary methylparaben (MeP), ethylparaben (EtP), propylparaben (PrP), butylparaben (BuP) measured by liquid chromatography/ tandem mass spectrometry. The cross-sectional analysis biomarkers also been established. Results MeP, EtP, PrP BuP (median) at 442, 42.9, 107 5.92 μg/L, respectively, which 10 times higher than those other countries. Subjects ≥55 yrs had MeP EtP DI <55 (Fig. 1 & Fig. 2). median was lotion, perfume nail polish users seldom 3). However, there no significant difference PCPs usage, or cumulative usage gender. creatinine, microalbumin, protein uric acid significantly men women, albumin creatinine ratio women (3.73 mg/g) (3.05 mg/g). Conclusion concentration adults US, Canada, Korea. There among levels, age source exposure.